A Novel Microfluidic Droplet Manipulation Method for Fabrication of Reverse-phase Two Layer Layer-by-layer Protein Microcapsules
نویسندگان
چکیده
This paper presents a novel droplet manipulation approach using high flow resistance microstructures for transferring microdroplets through different reagent streams for generating 2 layered polymeric-shell PSS/PEI microcapsules for biomolecular encapsulation. Our approach demonstrates the formation of protein capsules using the principle of ReversePhase Layer-by-Layer (RP-LbL) polyelectrolyte deposition. This is the first demonstration of RP-LBL in microfluidic devices and is a suitable, continuous method for encapsulating water soluble biomolecules.
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تاریخ انتشار 2013